2016 Annual Responsibility Review

In 2016, we worked with third party partner, The Carbon Trust, on a lifecycle assessment to recertify the product carbon footprints of three different bags of Flexbumin 25% [Albumin (Human)] sold in the U.S., Europe, Latin America, and Asia. From plasma collection, to manufacturing, distribution, and end-of-life, the assessment looked at the whole product lifecycle to understand where the biggest carbon impacts arose.

Across the U.S., there is a significant shortage of medical geneticists. With only one geneticist for every 600,000 individuals, the U.S. has less than half of the genetic workforce it needs. As an issue directly related to our business, we announced a $1.65 million grant to the ACMG Foundation for Genetic and Genomic Medicine. The ACMG Foundation is a non-profit organization that works to attract and fund training for the next generation of medical geneticists and genetic counselors. The Foundation also sponsors important research, and promotes information about medical genetics.

On October 7, Shire hosted its second annual Global Day of Service. More than one-third of our newly expanded workforce participated in volunteer projects worldwide. Employee volunteers dedicated over 25,000 hours of their time in more than 150 locations.

At Shire, we are committed to people of all races, genders and sexual orientations. We believe our collective differences provide a solid foundation for our sector-leading position. Harnessing our differences provides a wealth of ideas and innovations that allow us to be more responsive to customer needs.

Our focus on how we use resources improves efficiency, creates less waste, and reduces risks and impacts on the environment and our local communities.

It can take longer to diagnose rare diseases than many common diseases. On average, rare disease diagnosis takes 7.6 years in the U.S. and 5.6 years in the UK. Rare diseases such as the primary immunodeficiency (PI) disorders Gaucher disease, Fabry disease, and Hunter syndrome can be devastating, as they are difficult to detect and equally difficult to treat.